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A Comprehensive Review on Indole Nucleus with Therapeutic Significance

Author(s): Kashif Hussain1, MD. Jahangir Alam2, Afzal Hussain3, Neeraj Kumar4, Alok Kumar4, Anshu Raj4, Nadeem Ahmad Siddique1*

New drug synthesis is an outcomes of multiple reaction schemes considering several factors involved in reactions. Several challenges are hurdle for a scientist while designing a new drug such as feasibility of the reaction, stability of the compound and therapeutic target with anticipated potency as compared to established drug. Moreover, other challenges such as emerging rate of drug resistance against pathogens, critical regulatory constraints, safety of the synthesized compound and industrial scale up for large scale production. In last decade, several antibiotics or antimicrobial agents have been reported for less effective against reported microbes for which it was intended for. Several drugs are discovered as results of high throughput screening process. These are based on successful design, feasible reaction schemes and targeted therapeutic significance. The indole moiety of various heterocyclic drugs is the mother of several medicinal compounds possessing clinical benefits. Notably, recent advancements in synthetic medicinal chemistry, the progressive development witnessed multiple reports on a series of indole derivatives confirming these novel entities as an eminent therapeutic drug which targeted domain of drug discovery to overcome the challenges of health system. In last decades, research investigations published number of outstanding reports on indole based drug and its derivatives which withdrawn attentions of research scientists working in the same domain. Eventually, several such potential active molecules were translated into clinically commercial and approved products available in market followed with several in pipelines. In this review, we highlighted diverse application of indole or indole derivatives with recent achievements possessing biological, chemical and pharmacological activity.